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Researcher Home Page : Dr Ian Cree

Position Clinical Senior Lecturer and Hon. Consultant Pathologist (Moorfields Eye Hospital)
Department of Pathology
Institute of Ophthalmology
University College London
Qualifications BMSc (Hons), MB ChB, PhD, FRCPath
Specialty(s) Ophthalmic Pathology
Researcher Areas
  • Development of ATP-based chemosesensitivity assays
  • Development of new chemotherapy regimens, particularly for ocular melanoma
  • Trials of assay directed chemotherapy in ovarian cancer and melanoma
  • The molecular basis of eye melanoma
  • The role of new blood vessel formation in tumours and the eye

Recent Achievements

  • Development of the ATP-based chemosensitivity assay.
  • The demonstration that uveal melanoma is susceptible to chemotherapy
  • Development of the combination of treosulfan + gemcitabine chemotherapy for metastatic uveal melanoma. This has also now proven to be active in a number of more common tumours, including breast and ovarian cancer.
  • emonstration that loss of the TGFbeta pathway control of melanoma cell growth is a common event, and may be involved in the formation of the tumour.
  • Demonstration of the role of angiogenic factors in uveal melanoma and in iris neovascularisation in these patients.

Our work is performed in the context of a collabortive research effort with a number of associated laboratories in Germany and the USA. Much of this work would have been impossible without their involvment.

Editorial Board / Apppointments Director, CanTech Ltd (company registration number 3305194).
Honorary Staff Member, Imperial Cancer Research Fund (from June 1999)
Regional Editor, Pathology Oncology
Research Member, New Treatment Committee of the EORTC
Membership of Societies Fellow of the Royal College of Pathologists.
Fellow of the Royal College of Ophthalmologists (by election)
Member of the Pathological Society of Great Britain and Ireland.
Member of the Association of Clinical Pathologists (ACP).
Member of the British Division of the International Academy of Pathology.
Member of the Association for Research in Vision and Ophthalmology
Fellow of the Royal Society of Tropical Medicine and Hygiene.
Member of the International Leprosy Association
Member of the British Society for Immunology
Member of the British Medical Association Member of the Preclinical Therapeutic Models Group of the EORTC
Member of the Ocular Oncology Group of the EORTC (Elected council member)
Associate member of the National Cancer Institute (USA)
Founding member and vice-chairman, International Society for Chemosensitivity Testing in Oncology (ISCO).
Member, International Society for Bioluminescence and Chemiluminescence
Researcher Index
Last Updated : 20 August 2000
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